A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes.For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), Cdc48/p97 pulls polyubiquitinated, misfolded proteins out of the ER and
Yiqian Chen,1,* Jingzhen Chen,1,* Xingyu Chen,1,* Ru Wang,2 Jianqi Zeng,1 Feng Wang,3 Jiayin Miao1 1Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of China; 2Department of Neurology, Weinan Central Hospital, Weinan 714000, People’s Republic of China; 3School of Computer Engineering, Jime
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis.Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development.Moreover, MAG W D inhibition of oncogene-induced tumorigenesis relies on Arf and p53, but the requirements of Arf and p53
Unexploded ordnance (UXO) survey is the foremost task of clearance project.Transient electromagnetic method (TEM) is proved effective for UXO survey.However, it is still difficult for TEM Tooth Powders to detect small-size, ultra-shallow and dense UXO targets because the large-size devices and inversion methods for large-scale applications are usua
Urinary house soiling (periuria) in the home is a common but serious behaviour problem in cats.Although many specific risk factors and triggers have been postulated, their importance is largely unknown.This study assessed: (1) the significance of purported risk factors for periuria as well as specifically marking and latrine behaviour in the home;